Publications - Publications en-us PURE Extension (Web Department) 30 <![CDATA[Population characteristics of a large whale shark aggregation inferred from seawater environmental DNA]]> Sigsgaard, E. E., Nielsen, I. B., Bach, S. S., et al. Population genetics is essential for understanding and managing marine ecosystems, but sampling remains challenging. We demonstrate that high-throughput sequencing of seawater environmental DNA can provide useful estimates of genetic diversity in a whale shark (Rhincodon typus) aggregation. We recover similar mitochondrial haplotype frequencies in seawater compared to tissue samples, reliably placing the studied aggregation in a global genetic context and expanding the applications of environmental DNA to encompass population genetics of aquatic organisms.

Research Mon, 21 Nov 2016 23:06:44 +0100 6b45930f-ff8f-4c4c-b1a8-6c97a382255f
<![CDATA[Myxine jespersenae, a new species of hagfish (Myxiniformes: Myxinidae) from the North Atlantic Ocean]]> Møller, P. R., Feld, T. K., Poulsen, I. H., Thomsen, P. F., Thormar, J. G. Myxine jespersenae n. sp., described from the North Atlantic Ocean, occurs on the continental slopes off western Greenland and southern Iceland, at depths between 752 and 1556 m. It is diagnosed by a combination of two characters: two paired, pointed, or comb-shaped, bilaterally symmetrical nasal-sinus papillae with 2-5 distal fringes and two cusps fused at their bases in each teeth row. It is further characterized by the following combination of characters: 6 gill pouches; cusps totaling 38-44; coloration dark grayish brown with a white head, the white extending in a mid-ventral stripe of varying length; body slender (e.g., depth over cloaca 2.9-4.3 %TL); slime pores totalling 107-121. Myxine jespersenae n. sp. replaces the sympatric, but shallower occurring, M. glutinosa Linnaeus, 1758 on the Greenland-Iceland middle continental slope. Myxine glutinosa is here reported from East Greenland waters for the first time.

Research Sat, 01 Jan 2005 23:06:44 +0100 0eb4cb0f-595c-4c03-9c9e-984691b2f26b
<![CDATA[Detection of a Diverse Marine Fish Fauna Using Environmental DNA from Seawater Samples]]> Thomsen, P. F., Kielgast, J., Iversen, L. L., Møller, P. R., Rasmussen, M., Willerslev, E. Marine ecosystems worldwide are under threat with many fish species and populations suffering from human over-exploitation. This is greatly impacting global biodiversity, economy and human health. Intriguingly, marine fish are largely surveyed using selective and invasive methods, which are mostly limited to commercial species, and restricted to particular areas with favourable conditions. Furthermore, misidentification of species represents a major problem. Here, we investigate the potential of using metabarcoding of environmental DNA (eDNA) obtained directly from seawater samples to account for marine fish biodiversity. This eDNA approach has recently been used successfully in freshwater environments, but never in marine settings. We isolate eDNA from 1/2-litre seawater samples collected in a temperate marine ecosystem in Denmark. Using next-generation DNA sequencing of PCR amplicons, we obtain eDNA from 15 different fish species, including both important consumption species, as well as species rarely or never recorded by conventional monitoring. We also detect eDNA from a rare vagrant species in the area; European pilchard (Sardina pilchardus). Additionally, we detect four bird species. Records in national databases confirmed the occurrence of all detected species. To investigate the efficiency of the eDNA approach, we compared its performance with 9 methods conventionally used in marine fish surveys. Promisingly, eDNA covered the fish diversity better than or equal to any of the applied conventional methods. Our study demonstrates that even small samples of seawater contain eDNA from a wide range of local fish species. Finally, in order to examine the potential dispersal of eDNA in oceans, we performed an experiment addressing eDNA degradation in seawater, which shows that even small (100-bp) eDNA fragments degrades beyond detectability within days. Although further studies are needed to validate the eDNA approach in varying environmental conditions, our findings provide a strong proof-of-concept with great perspectives for future monitoring of marine biodiversity and resources.

Research Wed, 29 Aug 2012 23:06:44 +0200 5e0e0900-f113-4538-bb6e-31ffa909d324
<![CDATA[Protocol for a randomised controlled trial comparing warfarin with no oral anticoagulation in patients with atrial fibrillation on chronic dialysis]]> Ballegaard, E. L. F., Lindhard, K., Lindhardt, M., et al. INTRODUCTION: Atrial fibrillation is highly prevalent in patients on chronic dialysis. It is unclear whether anticoagulant therapy for stroke prevention is beneficial in these patients. Vitamin K-antagonists (VKA) remain the predominant anticoagulant choice. Importantly, anticoagulation remains inconsistently used and a possible benefit remains untested in randomised clinical trials comparing oral anticoagulation with no treatment in patients on chronic dialysis. The Danish Warfarin-Dialysis (DANWARD) trial aims to investigate the safety and efficacy of VKAs in patients with atrial fibrillation on chronic dialysis. The hypothesis is that VKA treatment compared with no treatment is associated with stroke risk reduction and overall benefit.

METHODS AND ANALYSIS: The DANWARD trial is an investigator-initiated trial at 13 Danish dialysis centres. In an open-label randomised clinical trial study design, a total of 718 patients with atrial fibrillation on chronic dialysis will be randomised in a 1:1 ratio to receive either standard dose VKA targeting an international normalised ratio of 2.0-3.0 or no oral anticoagulation. Principal analyses will compare the risk of a primary efficacy endpoint, stroke or transient ischaemic attack and a primary safety endpoint, major bleeding, in patients allocated to VKA treatment and no treatment, respectively. The first patient was randomised in October 2019. Patients will be followed until 1 year after the inclusion of the last patient.

ETHICS AND DISSEMINATION: The study protocol was approved by the Regional Research Ethics Committee (journal number H-18050839) and the Danish Medicines Agency (case number 2018101877). The trial is conducted in accordance with the Helsinki declaration and standards of Good Clinical Practice. Study results will be disseminated to participating sites, at research conferences and in peer-reviewed journals.

TRIAL REGISTRATION NUMBERS: NCT03862859, EUDRA-CT 2018-000484-86 and CTIS ID 2022-502500-75-00.

Research Mon, 26 Feb 2024 23:06:44 +0100 82345e1b-5c26-4c1e-a296-67dd5829644d
<![CDATA[Non-executive and Executive Managers: Individual Liability and Sanctions for Complicity in Competition Law Infringements]]> Jessen, P. W. Research Mon, 01 Jan 2024 23:06:44 +0100 f586fa62-1a59-43ff-99ea-f3f4be1e9b92 <![CDATA[Radiofrequency ablation of atrial fibrillation]]> Pontoppidan, J., Nielsen, J. C., Poulsen, S. H., et al. Research Thu, 01 Dec 2005 23:06:44 +0100 91e85631-58e0-4324-a369-a0ac67b2df47 <![CDATA[Difference between aortic and renal vascular reactivity in cyclosporin A treated rats and the effect of cicletanine]]> Mikkelsen, E. O., Poulsen, S. H., Nyborg, N. C.B., Korsgaard, N., Sehested, J. 4 Groups of 2 month-old male Wistar rats were treated with a) cyclosporin A (CyA) 30 mg/kg/day alone, b) CyA plus cicletanine (Cic) 60 mg/kg/day, c) vehicle (vegetable oil) 1 ml/100 g rat/day and d) no treatment for 8 weeks. The reactivity of isolated papillary muscle to isoprenaline and Ca 2+ was not altered in any of the treated groups. Endothelium-dependent relaxation induced by acetylcholine was inhibited in aorta ring segments from CyA treated rats as compared to that of control and CyA+Cic-treated rats. The relaxation induced by acetylcholine in rat aortas was similar in all groups in the presence of 10 μM indomethacin. Noradrenaline sensitivity of aortic segments was not affected by any treatments applied. The Ca2+-concentration response curves of aorta segments from CyA-treated and CyA+Cic-treated rats were shifted to the right as compared to control rats. In interlobar renal arteries the endothelium-dependent relaxation induced by acetylcholine was not affected by any form of treatment. In renal arteries 10 μM indomethacin increased the maximal relaxation induced by acetylcholine about 50%. In these vessels noradrenaline sensitivity in CyA and CyA+Cic treated rats was higher than in controls. Cocaine, 3 μM, shifted the noradrenaline concentration response curve to the left about 0.4 log units in all renal vessel groups, thus renal vascular smooth muscle sensitivity to noradrenaline was significantly greater in vessels from rats receiving CyA than in vessels from control rats. Administration of CyA induced only slight renal morphological changes. Cic was without effect on CyA induced morphological abnormalities. The results indicate that Cic is able to reverse the inhibitory effect of CyA on endothelium-dependent relaxations in aorta but does not affect the increased noradrenaline sensitivity of renal arteries associated with CyA treatment and was without effect on CyA induced changes in renal morphology. Treatment with CyA alone or in combination with Cic had no effect on the contractile force of the papillary muscle, indicating that CyA only affects function of vascular but not cardiac tissue.

Research Sun, 01 Mar 1992 23:06:44 +0100 2a6f8d40-78ca-4859-b50e-18b45522c40b
<![CDATA[Stereoselective Pharmacodynamic Action of (+)‐S‐12967 and (—)‐S‐12968, Isomers of a New Slow Acting 1, 4‐Dihydropyridine Derivative with Calcium Channel Agonistic and Antagonistic Effects on Rat Aorta]]> Poulsen, S. H., Nyborg, N. B.C., Mikkelsen, E. O. Abstract: The effects of (+)‐S‐12967 and (—)‐S12968, isomers of a new dihydropyridine (1, 4‐DHP) derivative [2(7‐amino 2, 5‐dioxaheptyl) 3‐ethoxycarbonyl 4‐(2, 3‐dichlorophenyl) 5‐methoxycarbonyl 6‐methyl 1, 4‐dihydropyridine] were studied on contractile responses of isolated thoracic aortas from rats and compared to that of nifedipine. The maximal relaxant effect of both isomers was reached in about 2 hr whereas the maximal relaxant effect to nifedipine was obtained within 30 min. The two 1, 4‐DPH isomers and nifedipine had a far more potent inhibitory effect on potassium (K+) than on noradrenaline (NA) induced contractions. They shifted the K+, Ca2+ and NA‐concentration response‐curves to the right and depressed the maximal vessel response to these agonists. Nifedipine was about 10 times more potent than the (—)‐isomer which again was about 100 times more potent that the (+)‐isomer. In contrast to nifedipine (–)‐S‐12968 and (+)‐S‐12967 had a dual action on K+ and Ca2+‐induced contractions as both isomers in low concentrations, 3×10–9M and 3×10–7M, respectively, shifted the K+‐concentration response curves to the left and increased the maximal response. In K+‐depolarized preparations they increased the response to low Ca2+‐concentrations without affecting the maximal vessel response at the highest Ca2+‐concentrations. The result indicates that (+)‐S‐12967 and (—)‐S‐12968 possess Ca2+‐agonistic as well as Ca‐antagonistic properties. Compared to nifedipine both isomers are slow acting vasodilators. Their action as regards their potency is stereoselective and the (—)‐isomer is more potent than the (+)‐isomer. 1992 Nordic Pharmacological Society

Research Wed, 01 Jan 1992 23:06:44 +0100 0de8726d-6d67-47c8-a321-cdc6aba2e88c
<![CDATA[Article 28/Schedule]]> Vedsted-Hansen, J. Research Mon, 01 Jan 2024 23:06:44 +0100 28e7bde8-8588-4360-965d-18093d48dc21 <![CDATA[Article 27]]> Vedsted-Hansen, J. Research Mon, 01 Jan 2024 23:06:44 +0100 f448f4ef-8c54-4ec4-b5d3-4fe94166b193 <![CDATA[Culture and management control interdependence: An analysis of control choices that complement the delegation of authority in Western cultural regions]]> Malmi, T., Bedford, D.S., Brühl, R., et al. Research Wed, 01 Jan 2020 23:06:44 +0100 e45c91e3-308e-4f61-8c6d-e3ed7136fe25 <![CDATA[En grundlovsmæssig beskyttelse af politisk ytringsfrihed?]]> Verdoner, S. A., Schmidt Rasmussen, K. Research Fri, 09 Feb 2024 23:06:44 +0100 7f6902bc-3f1b-4d6c-b65c-6f65eca6df77 <![CDATA[Social Enterprises in Denmark]]> Sørensen, K. E. Research Sun, 01 Jan 2023 23:06:44 +0100 8475e348-c640-4024-998b-77a0751bf3cb <![CDATA[Fuld skattepligt efter kildeskattelovens § 1, stk. 1, nr. 4, og lempelse efter ligningslovens § 33 A - SKM2023.286.SR]]> Laursen, A. N. Research Mon, 01 Jan 2024 23:06:44 +0100 6f72e28b-ae28-4d12-b198-67914e7d1d94 <![CDATA[Højesteretsdom om fristerne for ordinær og ekstraordinær skatteansættelse samt begrundelsesmangel - U 2023.5413 H]]> Laursen, A. N. Research Mon, 01 Jan 2024 23:06:44 +0100 f41e8ef5-9cd0-44a0-b62c-40e620db7fd8 <![CDATA[Denmark]]> Langkjær, L. H. Research Sun, 01 May 2022 23:06:44 +0200 13b0dcdf-b161-48d7-bc9f-fbf5e8ecf5c6 <![CDATA[Oprindelig sammenblanding under uskiftet bo]]> Sørensen, N. M. Research Mon, 01 Jan 2024 23:06:44 +0100 a7643b21-73ad-44bd-99f1-8d38fbded2a9 <![CDATA[EU Karnov 2023]]> Research Wed, 01 Nov 2023 23:06:44 +0100 8b09ea0d-8165-45f8-a1b4-918480d48a7b <![CDATA[Free Movement of Members of Corporate Management]]> Sørensen, K. E. Research Mon, 01 Jan 2024 23:06:44 +0100 a281cf1c-4b3b-4002-a3fe-e27264456139 <![CDATA[Statsstøtte]]> Jessen, P. W. Research Mon, 01 Jan 2024 23:06:44 +0100 368f34d4-92f5-4b19-a654-2e4c4c62a394 <![CDATA[Misbrug af dominerende stilling]]> Jessen, P. W. Research Mon, 01 Jan 2024 23:06:44 +0100 ae7606a2-e2e5-49b7-9446-bf8b4135c5f2 <![CDATA[Sustainable orbit and the Earth System: mitigation and regulation]]> Cirkovic, E., Potter, S., Acuff, K., Wood, D., Rathnasabapathy, M. Helsinki University1Western Colorado2Massachusetts Institute of Technology Media Lab3Bryce Space and Technology, LLC4. "This paper explores long-term sustainability issues related to increasing activities in outer space, with a particular focus on orbital debris. Adequately addressing these challenges requires a coordinated international and transdisciplinary approach to the evolving regulatory framework. Space sustainability holds particular significance for the achievement of Sustainable Development Goals (SDGs). Satellites are used to monitor climate change-induced variances and are especially useful for more remote areas, such as the Arctic, the ocean, and the atmosphere.

This paper aims to implement the proposal that orbital and planetary sustainability and the corresponding evolution of domestic, international, and regional instruments need to take place in the context of a promotion of Earth System sustainability. It also presents how a collaborative and transdisciplinary effort can address these challenges. This process would require inclusion of knowledge beyond the state-centric approach of international lawmaking and expanding Earth System sustainability models (Reduce, Reuse, Recycle; circular economies; Ecological Restoration; etc.) to encompass Earth’s orbits.

Due to the intensification of commercial uses of outer space, and open argumentation for the ‘colonization of outer space’, new regulation will need to account for the legacy of colonial experiences and the importance of indigenous knowledge for sustainable Earth and outer space. Traditional environmental knowledge (TEK) of the world’s indigenous peoples would need to gain a more equal status in the decision-making processes in order to enable this knowledge to be applied to the design of more sustainable practices for human operations in space. An important aspect of TEK is that it recognizes equality between human and nonhuman lives and spaces (the Earth System and outer space), and as such, challenges the more utilitarian approaches evident in mainstream proposals

Orbital debris poses a risk to functional satellites and threatens observation of the complex variables involved in climate change and environmental degradation. As explored in the framework EVDT (Environment-Vulnerability-Decision-Technology) of MIT’s Space Enabled Research Group, capturing together the environment, social impact, human decision-making, and technology as four domains with complex interaction, can enable us to engage with important challenges that lie at the intersection of these domains. The paper provides three approaches to these challenges. Section One looks at the different ontologies of outer space. It introduces the questions of traditional indigenous knowledge and increasing proposals for legal recognition of actors “beyond the human”. It then moves to two practical proposals for addressing sustainability in outer space and sustainable uses of outer space. Section Two will address the Space Sustainability Rating (SSR), a newly proposed incentive system designed to reward satellite operators that take actions to reduce space debris, in the context of international coordination bodies, regulation, and norms of behaviour, as well as the role of SSR in supporting existing long-term sustainability guidelines. Section Three argues that the space community may turn to terrestrial models aiming to manage this intersection in a sustainable manner. The application of models like the three “R’s” of sustainability (Reduce, Reuse, Recycle), initializing a circular economy, and tenets from the ecological restoration are explored in this paper.
Hence, to foster the exchange of best practices in the use of outer space and space applications for concrete climate change mitigation and/or climate-related adaptation activities, this paper argues for a more inclusive epistemic approach to norm production and lawmaking."]]>
Research Fri, 01 Jan 2021 23:06:44 +0100 60ef58e5-2c3e-478b-b9ac-fe128ad9cea2
<![CDATA[Dark & Quiet Skies II (2021)]]> Walker, C., Di Pippo, S., Aubé, M., et al. Research Fri, 01 Oct 2021 23:06:44 +0200 ec2fa9ef-022b-4240-a7d7-8610247a652e <![CDATA[SATCON2: Observations Working Group Report]]> Rawls, M. L., Barron, D., Birdwell, I., et al. Research Mon, 01 Nov 2021 23:06:44 +0100 f25a5ced-08fc-4288-908e-1e249e1bc7cb <![CDATA[After the Law]]> Cirkovic, E. Research Fri, 01 Dec 2023 23:06:44 +0100 0e3fa3b6-e4da-4871-9125-ca7ebbdf91d1 <![CDATA[Corporate opportunities i koncernforhold – en overset problemstilling i dansk selskabsret]]> Nielsen, J. B. M. Research Mon, 01 Jan 2024 23:06:44 +0100 cdff65ad-14ea-42f4-9b5c-7b7ba33c02be <![CDATA[The Earth system, the orbit, and international law]]> Cirkovic, E. Research Fri, 01 Jan 2021 23:06:44 +0100 b7a2d0ae-2d0c-475a-aefa-6889ea14b81d <![CDATA[IAU Dark and Quiet Skies, UNOOSA, NoirLabs, SATCON2, International Law Working Group Report]]> Cirkovic, E., Rawls, M. Research Fri, 01 Jan 2021 23:06:44 +0100 eb287f77-6174-429a-b818-8d20a1dd1259 <![CDATA[Global Legal Pluralism and Multipolar Conflicts]]> Cirkovic, E. Research Fri, 01 Dec 2006 23:06:44 +0100 ac56ee5e-6a3c-40cb-b337-b3c7aba9702d <![CDATA[An Analysis of the ICJ Advisory Opinion on Kosovo’s Unilateral Declaration of Independence]]> Cirkovic, E. Research Sun, 01 Aug 2010 23:06:44 +0200 84618010-b879-4f79-aa61-d14610994ca1 <![CDATA[Contested citizenship in Bosnia and Herzegovina]]> Cirkovic, E. Research Wed, 01 Jan 2014 23:06:44 +0100 7f41320b-d008-4cae-8cab-d74efc81fe85 <![CDATA[Fusionskontrol]]> Sørensen, K. E. Research Mon, 01 Jan 2024 23:06:44 +0100 54681f49-a6f9-4ce1-87c2-39f1537214a3 <![CDATA[Horisontale samarbejdsaftaler]]> Sørensen, K. E. Research Mon, 01 Jan 2024 23:06:44 +0100 dcaa2a9f-22c2-4c9a-8689-adbeb9b4dbf7 <![CDATA[Introduktion til art. 101]]> Sørensen, K. E. Research Mon, 01 Jan 2024 23:06:44 +0100 940ad1b4-91ef-4520-897b-a2796066b725 <![CDATA[Refugee and Human Rights Law Standards Applicable to Asylum Governance and the Right of Asylum]]> Vedsted-Hansen, J., Kienast, J., Feith Tan, N. Research Sun, 01 Jan 2023 23:06:44 +0100 466e1f93-bb7f-4f87-b74c-b5479d051dde <![CDATA[Civilprocesretlig Julealmanak - 2023]]> Torp, K. Communication Fri, 01 Dec 2023 23:06:44 +0100 de214119-f16d-4ec9-b9b0-2e76dd9f5c68 <![CDATA[Den danske 'midlertidige' grænsekontrol og EU-retten]]> Sørensen, K. E. Communication Fri, 01 Dec 2023 23:06:44 +0100 e903286c-c22f-422b-ae95-d7224cc4a66b <![CDATA[Ledelsens pligter og ansvar efter udkastet til et due diligence-direktiv]]> Sørensen, K. E. Research Sun, 01 Jan 2023 23:06:44 +0100 141efc01-3a2e-404d-ac9b-fc9acc0589cf <![CDATA[The Diversity of Third Sector Organisations in Denmark]]> Sørensen, K. E. Research Sun, 01 Jan 2023 23:06:44 +0100 845675c1-6f26-43df-a7da-829a95bba529 <![CDATA[Iagttager Kommissionens oprindelsesforordning legalitetsprincippet?]]> Jørgensen, C. W., Kjær, L. Research Wed, 01 Feb 2023 23:06:44 +0100 7dd89479-64c1-4192-80c4-396663d89e5f <![CDATA[Tilbagetrædelseserklæringer]]> Kristensen, L. H., Kure, H. Research Sun, 01 Jan 2023 23:06:44 +0100 26d86500-4317-4c2f-bf3c-b98f369a69c2 <![CDATA[Ny dansk arbetstidslag:]]> Munkholm, N. V. Communication Fri, 01 Dec 2023 23:06:44 +0100 b81ecf8e-0d58-4fef-9ca8-b3cf1cee4a9e <![CDATA[Den fælles patentdomstol - et regimeskifte i Europa!]]> Sommer, T., Fasmer Henum, V. ., Bording, N., Lindgreen, N. ., Schovsbo, J. Research Sun, 01 Jan 2023 23:06:44 +0100 76e22397-06f6-47ba-8c5f-475ced04dbe0 <![CDATA[EVERGREENING:]]> Schovsbo, J. ., Sommer, T. Research Fri, 01 Dec 2023 23:06:44 +0100 30a0c852-f42d-4f3d-8f4e-9c95e0c7f858 <![CDATA[Retsdogmatisk forskning 2024]]> Madsen, L. H. G. Education Mon, 01 Jan 2024 23:06:44 +0100 d8115870-c828-49aa-b07a-f834a69d1510 <![CDATA[Dansk markedsret]]> Mortensen, B. O. G., Steinicke, M. Research Sat, 01 Jan 2022 23:06:44 +0100 16417673-45d4-420e-a2f1-3a5fee441155 <![CDATA[Konkurrencerettens grænser]]> Steinicke, M. Research Fri, 01 Jan 2021 23:06:44 +0100 75e3ce0b-e548-4cd9-9b66-e90d95c44a1e <![CDATA[Exclusion]]> Steinicke, M. Research Sat, 01 Jan 2022 23:06:45 +0100 d45f3fab-cde3-4872-9e7c-4fa1104d8bc9 <![CDATA[Forsyningsenheder og udbudspligt]]> Steinicke, M. Research Sat, 01 Jan 2022 23:06:45 +0100 6c2933b4-2a9b-4ee3-ba34-b443e9145034 <![CDATA[Udbudsrettens indpas i Danmark]]> Steinicke, M. Research Tue, 10 Jan 2023 23:06:45 +0100 b156e033-0343-454c-8936-6c638bea2f7e